Multistep bioconversion of 20-deoxo-20-dihydro-12,13-deepoxy-12,13-dehydrorosaranolide to 22-hydroxy-23-o-mycinosyl-20-deoxo-20-dihydro-12,13-deepoxy-rosaramicin.
نویسندگان
چکیده
منابع مشابه
Dmm019919 1213..1225
Fatty liver disease is one of the main hepatic complications associated with obesity. To date, there are no effective treatments for this pathology apart from the use of classical fibrates. In this study, we have characterized the in vivo effects of a novel conjugation of oleic acid with an amphetamine derivative (OLHHA) in an animal model of genetic obesity. Lean and obese Zucker rats received...
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Reductive amination of the C-20 aldehyde group of tylosin and related macrolides yielded a large series of derivatives with potentially useful antibiotic properties. Evaluation of these new compounds was conducted on the basis of: 1) Broad antimicrobial spectrum in vitro, with particular emphasis on inhibition of Pasteurella multocida and Pasteurella haemolytica; 2) in vivo efficacy, especially...
متن کاملNpgRJ_NN_1959 1206..1213
Two behavioral phenomena characterize human motor memory consolidation: diminishing susceptibility to interference by a subsequent experience and the emergence of delayed, offline gains in performance. A recent model proposes that the sleepindependent reduction in interference is followed by the sleep-dependent expression of offline gains. Here, using the fingeropposition sequence–learning task...
متن کاملLimnol. Oceanogr., 45(6), 2000, 1213–1223
Total nitrogen (TN) and total phosphorus (TP) measurements and contemporaneous measurements of chlorophyll a (Chl a) and phytoplankton nutrient deficiency have been made across a broad range of lakes and ocean sites using common methods. The ocean environment was nutrient rich in terms of TN and TP when compared with most lakes in the study, although Lake Victoria had the highest values of TN a...
متن کامل1213 Conjunctival epithelial toxicity secondary to topical drug therapy
Pumose. To study ocular inflammation and comeal damage after short-term exposure to ultraviolet radiation (UVR). Method. Altogether, 200 Sprague-Dawley rats received during 15 mtn. unilaterally in viva 5 or 20 kJ/m* UVR (L= 300 nm, XO,~ = 10 nm). Following the UVR exposure, no other treatment was given. At 1, 2, 3, 4, 7, 28, 56, 112 and 224 days after exposure ocular inilammation, comeal damage...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1983
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.36.742